The target of rapamycin (TOR) proteins.
Identifieur interne : 001994 ( Main/Exploration ); précédent : 001993; suivant : 001995The target of rapamycin (TOR) proteins.
Auteurs : B. Raught [Canada] ; A C Gingras ; N. SonenbergSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2001.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antibactériens (pharmacologie), Apprentissage (physiologie), Humains (MeSH), Modèles biologiques (MeSH), Mémoire (physiologie), Phosphatidylinositol 3-kinases (MeSH), Phosphotransferases (Alcohol Group Acceptor) (métabolisme), Potentialisation à long terme (effets des médicaments et des substances chimiques), Potentialisation à long terme (physiologie), Protéines de Saccharomyces cerevisiae (MeSH), Protéines du cycle cellulaire (MeSH), Protéines fongiques (métabolisme), Ribosomes (effets des médicaments et des substances chimiques), Ribosomes (métabolisme), Saccharomyces cerevisiae (génétique), Sirolimus (pharmacologie), Synapses (effets des médicaments et des substances chimiques), Synapses (physiologie), Transduction du signal (effets des médicaments et des substances chimiques), Transduction du signal (physiologie), Élongation de la traduction (effets des médicaments et des substances chimiques), Élongation de la traduction (physiologie).
- MESH :
- effets des médicaments et des substances chimiques : Potentialisation à long terme, Ribosomes, Synapses, Transduction du signal, Élongation de la traduction.
- génétique : Saccharomyces cerevisiae.
- métabolisme : Phosphotransferases (Alcohol Group Acceptor), Protéines fongiques, Ribosomes.
- pharmacologie : Antibactériens, Sirolimus.
- physiologie : Apprentissage, Mémoire, Potentialisation à long terme, Synapses, Transduction du signal, Élongation de la traduction.
- Animaux, Humains, Modèles biologiques, Phosphatidylinositol 3-kinases, Protéines de Saccharomyces cerevisiae, Protéines du cycle cellulaire.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Bacterial Agents (pharmacology), Cell Cycle Proteins (MeSH), Fungal Proteins (metabolism), Humans (MeSH), Learning (physiology), Long-Term Potentiation (drug effects), Long-Term Potentiation (physiology), Memory (physiology), Models, Biological (MeSH), Peptide Chain Elongation, Translational (drug effects), Peptide Chain Elongation, Translational (physiology), Phosphatidylinositol 3-Kinases (MeSH), Phosphotransferases (Alcohol Group Acceptor) (metabolism), Ribosomes (drug effects), Ribosomes (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae Proteins (MeSH), Signal Transduction (drug effects), Signal Transduction (physiology), Sirolimus (pharmacology), Synapses (drug effects), Synapses (physiology).
- MESH :
- chemical , metabolism : Fungal Proteins, Phosphotransferases (Alcohol Group Acceptor).
- chemical , pharmacology : Anti-Bacterial Agents, Sirolimus.
- drug effects : Long-Term Potentiation, Peptide Chain Elongation, Translational, Ribosomes, Signal Transduction, Synapses.
- genetics : Saccharomyces cerevisiae.
- metabolism : Ribosomes.
- physiology : Learning, Long-Term Potentiation, Memory, Peptide Chain Elongation, Translational, Signal Transduction, Synapses.
- Animals, Cell Cycle Proteins, Humans, Models, Biological, Phosphatidylinositol 3-Kinases, Saccharomyces cerevisiae Proteins.
Abstract
Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. The TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation.
DOI: 10.1073/pnas.121145898
PubMed: 11416184
PubMed Central: PMC34619
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The target of rapamycin (TOR) proteins.</title><author><name sortKey="Raught, B" sort="Raught, B" uniqKey="Raught B" first="B" last="Raught">B. Raught</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montréal, QC H3G 1Y6 Canada.</nlm:affiliation><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Gingras, A C" sort="Gingras, A C" uniqKey="Gingras A" first="A C" last="Gingras">A C Gingras</name></author><author><name sortKey="Sonenberg, N" sort="Sonenberg, N" uniqKey="Sonenberg N" first="N" last="Sonenberg">N. Sonenberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11416184</idno><idno type="pmid">11416184</idno><idno type="doi">10.1073/pnas.121145898</idno><idno type="pmc">PMC34619</idno><idno type="wicri:Area/Main/Corpus">001A11</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001A11</idno><idno type="wicri:Area/Main/Curation">001A11</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001A11</idno><idno type="wicri:Area/Main/Exploration">001A11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The target of rapamycin (TOR) proteins.</title><author><name sortKey="Raught, B" sort="Raught, B" uniqKey="Raught B" first="B" last="Raught">B. Raught</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montréal, QC H3G 1Y6 Canada.</nlm:affiliation><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Gingras, A C" sort="Gingras, A C" uniqKey="Gingras A" first="A C" last="Gingras">A C Gingras</name></author><author><name sortKey="Sonenberg, N" sort="Sonenberg, N" uniqKey="Sonenberg N" first="N" last="Sonenberg">N. Sonenberg</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Cell Cycle Proteins (MeSH)</term><term>Fungal Proteins (metabolism)</term><term>Humans (MeSH)</term><term>Learning (physiology)</term><term>Long-Term Potentiation (drug effects)</term><term>Long-Term Potentiation (physiology)</term><term>Memory (physiology)</term><term>Models, Biological (MeSH)</term><term>Peptide Chain Elongation, Translational (drug effects)</term><term>Peptide Chain Elongation, Translational (physiology)</term><term>Phosphatidylinositol 3-Kinases (MeSH)</term><term>Phosphotransferases (Alcohol Group Acceptor) (metabolism)</term><term>Ribosomes (drug effects)</term><term>Ribosomes (metabolism)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae Proteins (MeSH)</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (physiology)</term><term>Sirolimus (pharmacology)</term><term>Synapses (drug effects)</term><term>Synapses (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antibactériens (pharmacologie)</term><term>Apprentissage (physiologie)</term><term>Humains (MeSH)</term><term>Modèles biologiques (MeSH)</term><term>Mémoire (physiologie)</term><term>Phosphatidylinositol 3-kinases (MeSH)</term><term>Phosphotransferases (Alcohol Group Acceptor) (métabolisme)</term><term>Potentialisation à long terme (effets des médicaments et des substances chimiques)</term><term>Potentialisation à long terme (physiologie)</term><term>Protéines de Saccharomyces cerevisiae (MeSH)</term><term>Protéines du cycle cellulaire (MeSH)</term><term>Protéines fongiques (métabolisme)</term><term>Ribosomes (effets des médicaments et des substances chimiques)</term><term>Ribosomes (métabolisme)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Sirolimus (pharmacologie)</term><term>Synapses (effets des médicaments et des substances chimiques)</term><term>Synapses (physiologie)</term><term>Transduction du signal (effets des médicaments et des substances chimiques)</term><term>Transduction du signal (physiologie)</term><term>Élongation de la traduction (effets des médicaments et des substances chimiques)</term><term>Élongation de la traduction (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term><term>Phosphotransferases (Alcohol Group Acceptor)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Long-Term Potentiation</term><term>Peptide Chain Elongation, Translational</term><term>Ribosomes</term><term>Signal Transduction</term><term>Synapses</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Potentialisation à long terme</term><term>Ribosomes</term><term>Synapses</term><term>Transduction du signal</term><term>Élongation de la traduction</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ribosomes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Phosphotransferases (Alcohol Group Acceptor)</term><term>Protéines fongiques</term><term>Ribosomes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apprentissage</term><term>Mémoire</term><term>Potentialisation à long terme</term><term>Synapses</term><term>Transduction du signal</term><term>Élongation de la traduction</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Learning</term><term>Long-Term Potentiation</term><term>Memory</term><term>Peptide Chain Elongation, Translational</term><term>Signal Transduction</term><term>Synapses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Cycle Proteins</term><term>Humans</term><term>Models, Biological</term><term>Phosphatidylinositol 3-Kinases</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Modèles biologiques</term><term>Phosphatidylinositol 3-kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines du cycle cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. The TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11416184</PMID><DateCompleted><Year>2001</Year><Month>07</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0027-8424</ISSN><JournalIssue CitedMedium="Print"><Volume>98</Volume><Issue>13</Issue><PubDate><Year>2001</Year><Month>Jun</Month><Day>19</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>The target of rapamycin (TOR) proteins.</ArticleTitle><Pagination><MedlinePgn>7037-44</MedlinePgn></Pagination><Abstract><AbstractText>Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. The TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Raught</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montréal, QC H3G 1Y6 Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gingras</LastName><ForeName>A C</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Sonenberg</LastName><ForeName>N</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018797">Cell Cycle Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D019869">Phosphatidylinositol 3-Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D017853">Phosphotransferases (Alcohol Group Acceptor)</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="C083324">TOR1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="C081135">TOR2 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018797" MajorTopicYN="N">Cell Cycle Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007858" MajorTopicYN="N">Learning</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017774" MajorTopicYN="N">Long-Term Potentiation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010441" MajorTopicYN="N">Peptide Chain Elongation, Translational</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019869" MajorTopicYN="Y">Phosphatidylinositol 3-Kinases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017853" MajorTopicYN="N">Phosphotransferases (Alcohol Group Acceptor)</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012270" MajorTopicYN="N">Ribosomes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="Y">Saccharomyces cerevisiae Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013569" MajorTopicYN="N">Synapses</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>132</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>6</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>7</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>6</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11416184</ArticleId><ArticleId IdType="doi">10.1073/pnas.121145898</ArticleId><ArticleId IdType="pii">98/13/7037</ArticleId><ArticleId IdType="pmc">PMC34619</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Cell. 1993 May 7;73(3):585-96</Citation><ArticleIdList><ArticleId IdType="pubmed">8387896</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7168-71</Citation><ArticleIdList><ArticleId IdType="pubmed">8102206</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1993 Oct;13(10):6012-23</Citation><ArticleIdList><ArticleId IdType="pubmed">8413204</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1993 Dec 23-30;366(6457):745-8</Citation><ArticleIdList><ArticleId IdType="pubmed">8264797</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 1994 Jan;5(1):105-18</Citation><ArticleIdList><ArticleId IdType="pubmed">8186460</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1994 Jun 30;369(6483):756-8</Citation><ArticleIdList><ArticleId IdType="pubmed">8008069</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1994 Jul 15;78(1):35-43</Citation><ArticleIdList><ArticleId IdType="pubmed">7518356</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 1994 Aug 30;203(1):1-7</Citation><ArticleIdList><ArticleId IdType="pubmed">7521160</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1994 Oct 27;371(6500):762-7</Citation><ArticleIdList><ArticleId IdType="pubmed">7935836</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1994 Oct 28;266(5185):653-6</Citation><ArticleIdList><ArticleId IdType="pubmed">7939721</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Immunopharmacol. 1994 Sep;16(9):711-21</Citation><ArticleIdList><ArticleId IdType="pubmed">7528736</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12574-8</Citation><ArticleIdList><ArticleId IdType="pubmed">7809080</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1995 Jan 13;270(2):815-22</Citation><ArticleIdList><ArticleId IdType="pubmed">7822316</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1995 Feb 3;270(5):2320-6</Citation><ArticleIdList><ArticleId IdType="pubmed">7836465</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14770-5</Citation><ArticleIdList><ArticleId IdType="pubmed">9405688</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1998 Jan;18(1):334-42</Citation><ArticleIdList><ArticleId IdType="pubmed">9418880</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Cell Biol. 1997 Dec;9(6):782-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9425342</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1997 Dec 26;91(7):927-38</Citation><ArticleIdList><ArticleId IdType="pubmed">9428516</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 1997 Dec 15;46(3):373-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9441740</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Feb 13;273(7):3963-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9461583</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9465032</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4264-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9539725</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurochem. 1998 May;70(5):2139-46</Citation><ArticleIdList><ArticleId IdType="pubmed">9572301</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 May 29;273(22):14002-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9593750</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Neurosci. 1998 May;21(5):181-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9610879</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7772-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9636226</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 1998 Jun 29;247(3):827-32</Citation><ArticleIdList><ArticleId IdType="pubmed">9647778</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 1998 Jul 15;92(2):539-46</Citation><ArticleIdList><ArticleId IdType="pubmed">9657754</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1998 Aug;18(8):4463-70</Citation><ArticleIdList><ArticleId IdType="pubmed">9671456</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 1998 Aug 15;334 ( Pt 1):261-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9693128</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurochem. 1998 Sep;71(3):1059-67</Citation><ArticleIdList><ArticleId IdType="pubmed">9721730</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Sep 4;273(36):23534-41</Citation><ArticleIdList><ArticleId IdType="pubmed">9722592</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1998 Dec 1;17(23):6924-31</Citation><ArticleIdList><ArticleId IdType="pubmed">9843498</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 1978 Oct;79(1):59-73</Citation><ArticleIdList><ArticleId IdType="pubmed">701378</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Physiol. 1980 Sep;104(3):269-81</Citation><ArticleIdList><ArticleId IdType="pubmed">7419605</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 1982 Mar;2(3):284-91</Citation><ArticleIdList><ArticleId IdType="pubmed">7062109</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1985 May 10;260(9):5493-7</Citation><ArticleIdList><ArticleId IdType="pubmed">3886657</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochemistry. 1985 Dec 17;24(26):7525-32</Citation><ArticleIdList><ArticleId IdType="pubmed">4092022</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochemistry. 1986 Apr 22;25(8):2033-41</Citation><ArticleIdList><ArticleId IdType="pubmed">3707930</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1986 Jul 31-Aug 6;322(6078):419-22</Citation><ArticleIdList><ArticleId IdType="pubmed">2874497</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comp Neurol. 1987 Oct 1;264(1):47-55</Citation><ArticleIdList><ArticleId IdType="pubmed">3680623</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1989 Jan 25;264(3):1748-53</Citation><ArticleIdList><ArticleId IdType="pubmed">2536373</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1989 Feb 15;264(5):2401-4</Citation><ArticleIdList><ArticleId IdType="pubmed">2914915</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1989 Oct 26;341(6244):755-7</Citation><ArticleIdList><ArticleId IdType="pubmed">2477714</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Growth Differ. 1996 Sep;7(9):1199-209</Citation><ArticleIdList><ArticleId IdType="pubmed">8877101</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1996 Nov;16(11):6242-51</Citation><ArticleIdList><ArticleId IdType="pubmed">8887654</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1996 Nov 8;271(45):28624-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8910494</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 1996 Nov 15;16(22):7171-81</Citation><ArticleIdList><ArticleId IdType="pubmed">8929426</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13445-52</Citation><ArticleIdList><ArticleId IdType="pubmed">8942955</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1997 Jan 31;275(5300):661-5</Citation><ArticleIdList><ArticleId IdType="pubmed">9005851</ArticleId></ArticleIdList></Reference><Reference><Citation>Histol Histopathol. 1997 Jan;12(1):25-31</Citation><ArticleIdList><ArticleId IdType="pubmed">9046040</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Genet Dev. 1997 Apr;7(2):170-5</Citation><ArticleIdList><ArticleId IdType="pubmed">9115420</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 1997 May 15;17(10):3445-54</Citation><ArticleIdList><ArticleId IdType="pubmed">9133370</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1997 Jul 4;277(5322):99-101</Citation><ArticleIdList><ArticleId IdType="pubmed">9204908</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1997 Oct 1;11(19):2522-31</Citation><ArticleIdList><ArticleId IdType="pubmed">9334317</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1997 Nov 7;272(45):28252-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9353277</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10624-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9380685</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1997 Dec 1;16(23):7196-206</Citation><ArticleIdList><ArticleId IdType="pubmed">9384596</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Jan 8;274(2):1058-65</Citation><ArticleIdList><ArticleId IdType="pubmed">9873051</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2000 Mar 10;275(10):7416-23</Citation><ArticleIdList><ArticleId IdType="pubmed">10702316</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1056-68</Citation><ArticleIdList><ArticleId IdType="pubmed">10749698</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2000 May;20(10):3558-67</Citation><ArticleIdList><ArticleId IdType="pubmed">10779345</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2000 May 23;97(11):6019-24</Citation><ArticleIdList><ArticleId IdType="pubmed">10811906</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2000 Jul;20(13):4604-13</Citation><ArticleIdList><ArticleId IdType="pubmed">10848587</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biochem. 1999;68:913-63</Citation><ArticleIdList><ArticleId IdType="pubmed">10872469</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2000 Jul 1;60(13):3504-13</Citation><ArticleIdList><ArticleId IdType="pubmed">10910062</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biochem. 2000;69:303-42</Citation><ArticleIdList><ArticleId IdType="pubmed">10966461</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2000 Oct 13;103(2):253-62</Citation><ArticleIdList><ArticleId IdType="pubmed">11057898</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2000 Nov 1;14(21):2689-94</Citation><ArticleIdList><ArticleId IdType="pubmed">11069885</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2000 Nov 1;14(21):2712-24</Citation><ArticleIdList><ArticleId IdType="pubmed">11069888</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13227-32</Citation><ArticleIdList><ArticleId IdType="pubmed">11078525</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2000 Dec 1;290(5497):1717-21</Citation><ArticleIdList><ArticleId IdType="pubmed">11099404</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14340-5</Citation><ArticleIdList><ArticleId IdType="pubmed">11114166</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2000 Dec 14-28;10(24):1574-81</Citation><ArticleIdList><ArticleId IdType="pubmed">11137008</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2001 Jan 15;21(2):382-91</Citation><ArticleIdList><ArticleId IdType="pubmed">11160419</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Mar 9;276(10):7027-32</Citation><ArticleIdList><ArticleId IdType="pubmed">11096119</ArticleId></ArticleIdList></Reference><Reference><Citation>J Antibiot (Tokyo). 1975 Oct;28(10):721-6</Citation><ArticleIdList><ArticleId IdType="pubmed">1102508</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1978 Jan;75(1):108-12</Citation><ArticleIdList><ArticleId IdType="pubmed">272626</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1989 Oct 26;341(6244):758-60</Citation><ArticleIdList><ArticleId IdType="pubmed">2477715</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1990 Mar;10(3):1134-44</Citation><ArticleIdList><ArticleId IdType="pubmed">2304461</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1990 Jun 25;265(18):10611-6</Citation><ArticleIdList><ArticleId IdType="pubmed">2191953</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1990 Dec 5;265(34):21011-5</Citation><ArticleIdList><ArticleId IdType="pubmed">1701173</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1991 Aug 23;253(5022):905-9</Citation><ArticleIdList><ArticleId IdType="pubmed">1715094</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 1992 Mar;12(3):762-72</Citation><ArticleIdList><ArticleId IdType="pubmed">1545238</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1992 Apr 15;267(11):7269-74</Citation><ArticleIdList><ArticleId IdType="pubmed">1559971</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1992 Nov 15;267(32):23226-31</Citation><ArticleIdList><ArticleId IdType="pubmed">1429670</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1995 Sep;15(9):4990-7</Citation><ArticleIdList><ArticleId IdType="pubmed">7651417</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1995 Oct 6;83(1):1-4</Citation><ArticleIdList><ArticleId IdType="pubmed">7553860</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1995 Oct 6;270(5233):50-1</Citation><ArticleIdList><ArticleId IdType="pubmed">7569949</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1995 Nov 15;14(22):5701-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8521827</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1996 Jan;16(1):405-13</Citation><ArticleIdList><ArticleId IdType="pubmed">8524322</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1996 May 1;15(9):2291-7</Citation><ArticleIdList><ArticleId IdType="pubmed">8641294</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Immunol. 1996;14:483-510</Citation><ArticleIdList><ArticleId IdType="pubmed">8717522</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1996 Aug 1;10(15):1904-16</Citation><ArticleIdList><ArticleId IdType="pubmed">8756348</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1996 Sep 6;273(5280):1402-6</Citation><ArticleIdList><ArticleId IdType="pubmed">8703078</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Neurosci. 1996 Jun;19(6):215-8</Citation><ArticleIdList><ArticleId IdType="pubmed">8761954</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 1996 Jan;7(1):25-42</Citation><ArticleIdList><ArticleId IdType="pubmed">8741837</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Genet Dev. 1999 Feb;9(1):49-54</Citation><ArticleIdList><ArticleId IdType="pubmed">10072357</ArticleId></ArticleIdList></Reference><Reference><Citation>Development. 1999 Apr;126(8):1601-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10079223</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 1999 Mar 5;446(1):108-12</Citation><ArticleIdList><ArticleId IdType="pubmed">10100624</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Neurosci. 1998 Nov;1(7):563-71</Citation><ArticleIdList><ArticleId IdType="pubmed">10196563</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 1999 Apr;10(4):987-1000</Citation><ArticleIdList><ArticleId IdType="pubmed">10198052</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 1999 May 15;340 ( Pt 1):135-41</Citation><ArticleIdList><ArticleId IdType="pubmed">10229668</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1999 May 17;18(10):2782-92</Citation><ArticleIdList><ArticleId IdType="pubmed">10329624</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1999 May 14;284(5417):1161-4</Citation><ArticleIdList><ArticleId IdType="pubmed">10325225</ArticleId></ArticleIdList></Reference><Reference><Citation>Neuroscience. 1999;91(1):233-49</Citation><ArticleIdList><ArticleId IdType="pubmed">10336074</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1999 Jun 1;13(11):1422-37</Citation><ArticleIdList><ArticleId IdType="pubmed">10364159</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 1999 Jun;3(6):707-16</Citation><ArticleIdList><ArticleId IdType="pubmed">10394359</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 1999 Sep 3;457(3):489-93</Citation><ArticleIdList><ArticleId IdType="pubmed">10471835</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 1999 Sep 20;146(6):1227-38</Citation><ArticleIdList><ArticleId IdType="pubmed">10491387</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 1999 Oct;121(2):609-17</Citation><ArticleIdList><ArticleId IdType="pubmed">10517853</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1995 Mar 15;154(6):2714-23</Citation><ArticleIdList><ArticleId IdType="pubmed">7876543</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1999 Oct 15;99(2):221-37</Citation><ArticleIdList><ArticleId IdType="pubmed">10535740</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Neurosci. 1999 Sep;14(3):180-98</Citation><ArticleIdList><ArticleId IdType="pubmed">10576889</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Biochem Sci. 1999 Nov;24(11):437-40</Citation><ArticleIdList><ArticleId IdType="pubmed">10542411</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 1999 Dec 1;344 Pt 2:427-31</Citation><ArticleIdList><ArticleId IdType="pubmed">10567225</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1999 Dec 9;402(6762):689-92</Citation><ArticleIdList><ArticleId IdType="pubmed">10604478</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Cell Dev Biol. 1999;15:1-32</Citation><ArticleIdList><ArticleId IdType="pubmed">10611955</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14866-70</Citation><ArticleIdList><ArticleId IdType="pubmed">10611304</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1999 Dec 15;13(24):3271-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10617575</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2000 Feb 1;19(3):434-44</Citation><ArticleIdList><ArticleId IdType="pubmed">10654941</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Neurosci. 2000 Mar;3(3):211-6</Citation><ArticleIdList><ArticleId IdType="pubmed">10700251</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):980-4</Citation><ArticleIdList><ArticleId IdType="pubmed">8430112</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Gingras, A C" sort="Gingras, A C" uniqKey="Gingras A" first="A C" last="Gingras">A C Gingras</name><name sortKey="Sonenberg, N" sort="Sonenberg, N" uniqKey="Sonenberg N" first="N" last="Sonenberg">N. Sonenberg</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Raught, B" sort="Raught, B" uniqKey="Raught B" first="B" last="Raught">B. Raught</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001994 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001994 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:11416184
|texte= The target of rapamycin (TOR) proteins.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:11416184" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |